diff --git a/group_vars/matrix_servers b/group_vars/matrix_servers
index e5ce1027..b4e5ac6e 100755
--- a/group_vars/matrix_servers
+++ b/group_vars/matrix_servers
@@ -1239,6 +1239,11 @@ matrix_nginx_proxy_proxy_matrix_user_directory_search_addr_sans_container: "{{ m
 
 matrix_nginx_proxy_self_check_validate_certificates: "{{ false if matrix_ssl_retrieval_method == 'self-signed' else true }}"
 
+# OCSP stapling does not make sense when self-signed certificates are used.
+# See https://github.com/spantaleev/matrix-docker-ansible-deploy/issues/1073
+# and https://github.com/spantaleev/matrix-docker-ansible-deploy/pull/1074
+matrix_nginx_proxy_ocsp_stapling_enabled: "{{ matrix_ssl_retrieval_method != 'self-signed' }}"
+
 matrix_nginx_proxy_synapse_presence_disabled: "{{ not matrix_synapse_presence_enabled }}"
 
 matrix_nginx_proxy_synapse_workers_enabled: "{{ matrix_synapse_workers_enabled }}"